Eitoku Academy is a school that caters to children and from rich, high-society families. Hence, Makino, who comes from a poor family, is considered by others as the "weed" of the school. The school is ruled by the "Flower Four" group, more commonly known as the F4. The F4 leader, and son of the wealthiest, most powerful family in Japan, Domyouji Tsukasa, takes an interest in Tsukushi because she is the only girl at Eitoku who does not fawn over him. However, his hot-headed nature and bullying ways are originally a major turn-off for Tsukushi, who has her sights set on Rui Hanazawa.